It appears, if after closing the welcome page, you attempt to personalise a profile, it will select the 'Collection Spotlight' profile instead of the selected one.

To reproduce, click on any profile. Then click 'File->Welcome Page'. From there click ok.

Then right click 'personalise' of your previously selected profile.

I actually found it, by starting dvdprofiler, closing the welcome page and then going to personalise the first profile as that is the one I wanted to change things on. But the above method also has the same effect.

Selecting 'DVD->Personalise' also has the same effect.

Here are a couple of links to screen shots.

Welcome page

and

Personalise page

You can see that 'Hot Fuzz' is my selected profile, but once the welcome page is closed, it uses sling blade if you try and personalise it.

If you try and do a 'DVD->Change Ean' it also selects the wrong profile. But changing the locality or editing the profile does the correct one.